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22-09-2019
| 15:00 | - | Rennes - : - Lille |  |
| 21:00 | - | Lyon - : - PSG | |
| 17:30 | - | Chelsea - : - Liverpool | |
| 12:30 | - | Sassuolo - : - Spal | |
| 15:00 | - | Bologne FC - : - AS Roma | |
| 15:00 | - | Lecce - : - Naples | |
| 16:00 | - | Young Boys - : - FC Bâle | |
| 16:00 | - | FC Zürich - : - FC Thun | |
| 14:00 | - | AEL Larissa - : - Xanthi | |
| 18:30 | - | Lamia FC - : - Panionios | |
| 12:15 | - | Heerenveen - : - Utrecht | |
| 14:30 | - | FC Emmen - : - Feyenoord | |
| 15:00 | - | Arezzo - : - Albinoleffe | |
| 17:30 | - | Lecco - : - AC Monza | |
| 17:30 | - | Fano - : - AC Reggiana | |
| 12:00 | - | Alavés B - : - Izarra | |
| 12:00 | - | Prat - : - Andorre CF | |
| 12:00 | - | SD Ejea - : - CD Ebro | |
| 18:00 | - | Somozas - : - CSD Arzua | |
| 18:00 | - | Arosa - : - Silva SD | |
| 18:00 | - | Barco - : - Bergantinos | |
| 12:00 | - | Conquense - : - Illescas | |
| 18:00 | - | Ciudad Real - : - Toledo | |
| 12:00 | - | CD Lealtad - : - Urraca | |
| 12:00 | - | Covadonga - : - Condal | |
| 17:30 | - | Mosconia - : - Praviano | |
| 17:30 | - | CD Cayón - : - Selaya FC | |
| 11:30 | - | Deusto - : - Santurtzi | |
| 11:30 | - | Sodupe - : - SCD Durango | |
| 11:30 | - | Somorrostro - : - Tolosa | |
| 11:00 | - | Elche B - : - Novelda CF | |
| 19:00 | - | UD Alzira - : - CD acero | |
| 12:00 | - | AD Ceuta - : - Xerez CD | |
| 18:00 | - | CD Rota - : - Ecija | |
| 18:30 | - | Arcos CF - : - Cordoba B | |
| 17:00 | - | Cirbonero - : - Burlades | |
| 17:00 | - | CD Berceo - : - CD Varea | |
| 17:00 | - | CD Brea - : - Utebo FC | |
| 14:00 | - | Stuttgart II - : - Linx | |
| 12:15 | - | Leixoes - : - Benfica B | |
| 17:00 | - | CD Mafra - : - Varzim | |
| 15:00 | - | CS Visé - : - RFC Liège | |
| 14:00 | - | FC Lori - : - Ararat | |
| 15:00 | - | Pyunik - : - FC Noah | |
| 16:30 | - | Rudeš - : - Dugopolje | |
| 13:00 | - | Avarta - : - Holbæk B&IF | |
| 16:00 | - | HK - : - IA Akranes | |
| 12:00 | - | Zhetysu - : - FC Astana | |
| 14:00 | - | Ordabasy - : - FK Aktobe | |
| 18:00 | - | Ranheim - : - Bodo/Glimt | |
| 15:00 | - | Nest-Sotra - : - Skeid | |
| 15:00 | - | HamKam - : - IK Start | |
| 15:00 | - | Sola - : - IL Hødd | |
| 18:00 | - | Bryne FK - : - Moss FK | |
| 14:00 | - | FK Senja - : - Asane | |
| 15:00 | - | Alta IF - : - Kjelsas IL | |
| 16:00 | - | Asker - : - Sotra SK | |
| 12:00 | - | FK Zorkiy - : - Ryazan | |
| 18:00 | - | NŠ Mura - : - NK Celje | |
| 17:30 | - | Elfsborg - : - Malmö FF | |
| 17:00 | - | Oddevold - : - Lunds BK | |
| 13:00 | - | Umea - : - BK Forward | |
| 15:00 | - | Boden BK - : - Gefle IF | |
| 20:30 | - | CA Lanus - : - CA Colón | |
| 01:30 | 22' | Blooming 0 : 0 San Jose | |
| 00:00 | 90' | Corinthians 2 : 1 EC Bahia | |
| 02:00 | - | FC Santos - : - Gremio | |
| 21:00 | - | CSA - : - Ceara | |
| 00:00 | Term. | Cuiaba 2 : 0 Oeste | |
| 00:00 | 90' | Monterrey 3 : 2 Club Puebla | |
| 00:00 | Term. | Necaxa 2 : 4 Club León | |
| 00:00 | Term. | Atlético San Luis 2 : 3 Santos Laguna | |
| 00:00 | Term. | Zacatepec 2 : 1 Correcaminos UAT | |
| 21:00 | - | Cerro - : - Danubio | |
| 01:30 | 17' | FC Cincinnati 0 : 0 Chicago Fire | |
| 19:35 | - | Kazma - : - Yarmouk | |
| 15:00 | - | Perak FA - : - Selangor |
| 14:00 | - | Zoo Kericho - : - Tusker |
| 14:00 | - | SoNy Sugar - : - Bandari |
| 15:15 | - | Gor Mahia - : - KCB |
| 17:30 | - | Wadi Degla - : - Tanta | |
| 10:15 | - | Slovacko II - : - Znojmo | |
| 14:00 | - | VJS - : - JIPPO | |
| 17:30 | - | MiPK - : - Kiffen | |
| 14:00 | - | GBK - : - JS Hercules | |
| 14:00 | - | OLS - : - Jakobstads | |
| 14:00 | - | PK-37 - : - SJK-2 | |
| 18:00 | - | Kerkyra - : - Panachaiki | |